The basic helix-loop-helix (bHLH) transcription factor family is one of the largest transcription factor families in both animals and plants. More than 630 bHLH transcription factors have been identified in several important food crops 1, and based on genome-wide analyses, 167, 177, 190 and at least 191 bHLH transcription factors have been predicted in the Arabidopsis thaliana L., Oryza sativa.
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right.
The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. Long TA(1), Tsukagoshi H, Busch W, Lahner B, Salt DE, Benfey PN. Author information: (1)Department of Biology and Institute for Genome Science and Policy Center for Systems Biology, Duke University, Durham, North Carolina 27708, USA. Global population increases and climate change underscore the.
This article presents a brief review on progress achieved in studies related to the classification, origination and functions of bHLH transcription factor families. Discover the world's research.
TFClass is a classification of eukaryotic transcription factors based on the characteristics of their DNA-binding domains. It comprises four general levels (superclass, class, family, subfamily) and two levels of instantiation (genus and molecular species). Two of them (subfamily and factor species) are optional. More detailed explanations about the classification scheme and its criteria are.
A sigma factor is a protein needed only for initiation of RNA synthesis in bacteria. Sigma factors provide promoter recognition specificity to the RNA polymerase (RNAP) and contribute to DNA strand separation, then dissociating from the RNA polymerase core enzyme following transcription initiation. The RNA polymerase core associates with the sigma factor to form RNA polymerase holoenzyme.
Based on sequence homology and phylogenetic relationships, bHLH transcription factors are usually classified into six groups (from A to F) in animals (12,13).These groups can be divided into several small subfamilies ().The six bHLH transcription factor groups diverge in function and binding elements ().Group A contains proteins such as MyoD and Twist and can bind to the E-box (CAGCTG).
Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA (deoxyribonucleic acid) is transcribed into RNA (ribonucleic acid). The enzyme RNA polymerase catalyzes the chemical reactions that synthesize RNA, using the gene’s DNA as a template. Transcription factors control when, where, and how efficiently RNA polymerases function.
Transcription factors, in a somewhat simplified definition, are proteins that regulate transcription by binding to specific sequence elements in regulatory genome regions such as promoters, enhancers etc.. TFClass is a classification of eukaryotic transcription factors based on the characteristics of their DNA-binding domains (DBDs).
Any protein that is needed for the initiation of transcription is defined as a transcription factor. Many transciption factors act by recognizing. Members of the group with such a region are called bHLH proteins. A dimer in which both subunits have the basic region can bind to DNA. The bHLH proteins fall into 2 general groups. Class A consists of proteins that are ubiquitously expressed.
Transcription factor bHLH70. Alternative name(s): Basic helix-loop-helix protein 70. Short name: AtbHLH70. Short name: bHLH 70. Transcription factor EN 13. bHLH transcription factor bHLH070 Gene names i: Name:BHLH70. Synonyms: EN13. Ordered Locus Names: At2g46810. ORF Names: F19D11.9. Organism i: Arabidopsis thaliana (Mouse-ear cress) Taxonomic.
In this study, we show that the bHLH transcription factor bHLH115 is a positive regulator of the Fe-deficiency response. Loss-of-function of bHLH115 causes strong Fe-deficiency symptoms and.
TCF12 (transcription factor 12) NR4A3 (nuclear receptor subfamily 4, group A, member 3) TFAP2C (transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)) TFE3 (transcription factor E3) TFEB (transcription factor EB) TGFB1 (transforming growth factor, beta 1) THRAP3 (thyroid hormone receptor associated protein 3).
Any cell making a myogenic bHLH transcription factor such as MyoD or Myf5 is committed to becoming a muscle cell. Myogenic regulatory factors (proper name?) Later than the MyoD proteins expression during differentiation, the myogenin and the myogenic regulatory factor 4 (MRF4) are present. Mice with deleted myogenin in developing myoblasts can.
A bstract: A significant reduction or loss of goblet cells is often observed in clinical samples of colon adenocarcinomas, which is the predominant form of colon carcinoma. Mice lacking Math1, a bHLH transcription factor downstream of the Notch signaling pathway, demonstrates that Math1 is necessary for cell fate determination of the intestinal secretory cells, including goblet cells.Plant growth, development and interaction with the environment involve the action of multiple phytohormones. Transcription factors (TFs) of diverse families play essential roles in the signalling cascades triggered by the perception of a particular hormone. TFs may act alone or in a combinatorial fashion with other TFs, and may act specifically in a single hormonal signalling cascade or as.Although extensive chemical and pharmaceutical studies of these compounds have been performed, studies on the basic helix-loop-helix (bHLH) transcription factors that regulate tanshinone biosynthesis are limited. In our study, 127 bHLH transcription factor genes were identified in the genome of S. miltiorrhiza, and phylogenetic analysis indicated that these SmbHLHs could be classified into 25.